Abstract  :  
                                    Aim: This  study  was  two  folded:  an  in-vivo  study  to  compare  the  retentive  properties  of  Lucitone  conventional  cured  denture  base  resin  and  Nature-Cryl  MC  microwave  cured  denture  base resin and an in-vitro study to compare the internal adaptation, fracture resistance, roughness, hardness and colour stability of these two materials and correlate the laboratory results with each other and with the clinical results.Materials  and  Methods:  Twenty  completely  edentulous  male  patients  received  twenty  complete dentures constructed from Lucitone conventional cured denture base resin. The retentive properties  of  the  upper  complete  dentures  were  measured  using  force  measurement  gauge  at  one  week,  one  month  and  three  month  follow-up  period.  The  patients  were  instructed  to  take  off  their  dentures  for  two  weeks.  Twenty  complete  dentures  were  then  constructed  for  the  same  patients  using  Nature-Cryl  MC  microwave  cured  denture  base  resin.  The  retentive  properties  of  the  upper  complete  dentures  were  also  measured  using  force  measurement  gauge  at  one  week,  one month and three month follow-up period. After finishing the in-vivo retention measurements, the twenty patients were equally divided into two groups based on their clinical satisfaction; one group received Lucitone denture base resin and the other group received Nature-Cryl MC denture base  resin.  The  other  twenty  dentures;  ten    made  of  Lucitone  and  ten  made  of  Nature-Cryl  MC  were taken for laboratory testing. Internal adaptation was evaluated by weighing a silicon film between each denture base and the metal master mode using a precision scale. Fracture test was carried out by applying compressive mode of load at fitting surface of each denture using computer controlled  materials  testing  machine.  For  measuring  surface  roughness  and  surface  hardness,  twenty rectangular specimens assigned to two equal groups; Lucitone conventional cured resin and Nature-Cryl MC microwave cured resin where prepared. Using 3D image of the surface profile of the specimens, WSxM software was used to calculate average of heights expressed in μm, which was assumed as a reliable indices of surface roughness. Hardness was then measured using Vicker’s hardness  tester.  Forty  cuboidal  specimens  assigned  to  two  equal  groups;  Lucitone  conventional  cured  resin  and  Nature-Cryl  MC  microwave  cured  resin  where  then  prepared  for  measuring  color stability using solutions of tea, coffee, and turmeric and artificial saliva. Five specimens of each acrylic resin brand were immersed into each of the specific solutions for three days and the specimens’ colors were measured using a Reflective Spectrophotometer. All results of in-vivo and in-vitro investigations were collected and tabulated for statistical analysis.           Results: The clinical results of the retention were in agreement with the laboratory results of internal adaptation as both showed statistically non-significant difference between both denture base  materials.  The  laboratory  results  of  physical  properties  showed  higher  fracture  resistance,  lower roughness, higher hardness and lower colour change of Lucitone conventional cured denture base resin in comparison to Nature-Cryl MC microwave cured denture base resin. Conclusion: There is no difference between dentures constructed from Lucitone and dentures constructed from Nature-Cryl MC in terms of retention and internal adaptation. However, Lucitone conventional  cured  denture  base  resin  has  superior  physical  properties  than  Nature-Cryl  MC  in  terms  of  higher  fracture  resistance  and  hardness  values  and  lower  roughness  and  colour  change  values. In-vivo measurements of denture retention and in-vitro measurements of internal adaptation are correlated. Results of hardness and fracture resistance are correlated. Results of roughness and colour  changes  are  correlated.  Tests  for  physical  properties  and  other  applications  of  microwave  cured resin should be continued.